Significant Difference on Structure Analysis
The 'Significant difference' option is available under Advanced Settings.
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It is set to 'Off' by default.
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The legend referring to 'Significant Difference' can be found under the chart.
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The sample total is the base set by default. This can be changed under the Advanced Settings 'Base' option.

These icons display the 'Significant Difference'.
When creating a Structure Analysis visualization, you might enable indication of Significant differences for each given series between categories.